'When you see the tragedies these viruses cause, it's very frustrating that we can't do more to help people. It'll be some time before we can use these vaccines in the field, but it's satisfying to know that we're getting closer.'

Researchers from the Public Health Agency of Canada and the US Army Medical Research Institute of Infectious Diseases collaborated in developing and testing the vaccines.

In a study published in this month's Nature Medicine, Canadian researchers Dr. Heinz Feldmann and Dr. Steven Jones of PHAC's National Microbiology Laboratory and Dr. Thomas Geisbert of USAMRIID report that the vaccines have proven 100 percent effective in protecting monkeys against infection from these often-deadly viruses.

'Goes Exactly Where We Want It to Go'

Monkeys are known to develop hemorrhagic fever symptoms that are similar to those observed in infected humans. Demonstrating that these vaccines are safe and effective in monkeys is a promising indicator of their real potential for use in human populations.

"When you see the tragedies these viruses cause, it's very frustrating that we can't do more to help people," said Dr. Feldmann, who -- along with Dr. Jones and others from PHAC -- has been providing on-site rapid diagnostic support to the current Marburg outbreak in Angola. "It'll be some time before we can use these vaccines in the field, but it's satisfying to know that we're getting closer."

This is the first vaccine system, or platform, that has protected nonhuman primates from both Ebola and Marburg, according to Dr. Geisbert.

"In addition, the vaccine targets dendritic cells, which are the same cells that Ebola and Marburg attack," he noted. "These cells are also important in generating a protective immune response. So the vaccine goes exactly where we want it to go."

Benefits of Collaborative Research

The study describes how Canadian researchers developed the vaccines by replacing a surface protein in an animal pathogen, called "vesicular stomatitis virus," with a surface protein from either the Ebola or Marburg viruses. Following extensive work, including trials with mice and guinea pigs, the PHAC researchers collaborated with USAMRIID to prove their efficacy in non-human primates.

Canadian Health Minister Ujjal Dosanjh and Dr. Carolyn Bennett, Minister of State (Public Health), praised the work of the scientists in developing the vaccine and providing support to the outbreak in Angola.

"This speaks volumes about the dedication and expertise of these individuals, and also what can be achieved through international collaboration," said Minister Dosanjh.

People everywhere could benefit from the vaccine development, Minister Bennett added, "in stopping outbreaks where they originate as well as reducing the risk that these viruses will be used in bioterrorism."

The study illustrates the benefits of collaborative research to develop medical countermeasures for biodefense, said Colonel Erik A. Henchal, commander of USAMRIID. "Relationships like this contribute to better science and ultimately better protection for military service members and civilians alike."